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Paul Harrison

Phil Holmes

Ruth Bevan


Publication Lists:
Paul Harrison
Phil Holmes
Ruth Bevan

Committee Memberships

 

 

 

The Directors

The Directors at IEH Consulting together bring with them many decades of experience in toxicology and risk assessment, gained in various organisations including industry, academia, government and government research institutes, independent consultancy and contract toxicology sectors. In addition, we have a number of highly experienced Associates with whom we work to expand both the range of expertise and the capacity we can offer. 

Details of the Directors Paul Harrison, Philip Holmes and Dr Ruth Bevan are summarised below:

Professor Paul T C Harrison BSc, PhD, Grad Cert Ed (Coll), CBiol, FSB, FBTS

Paul has worked as an independent consultant since 2008 and is Owner/Director of PTCH Consultancy Limited. He is a Fellow of the Society of Biology and the British Toxicology Society, and until recently was Visiting Professor in Environment and Health at Cranfield University.

Paul’s previous positions have included Senior Toxicologist at BP’s Occupational Health Centre where he was responsible for advising on the toxicity of various chemicals and products and for the unit’s research quality assurance programme. He joined the UK Department of the Environment in 1991 and became Head of the Indoor Air Quality and Major Accidents Branch of the Toxic Substances Division before being seconded to the Medical Research Council in October 1993 to help establish the Institute for Environment and Health (MRC-IEH) at Leicester University. He was appointed Acting Director of MRC-IEH in July 1998, and became Director of the Institute when it moved to Cranfield University in November 2005.

Paul has held positions on various expert groups and committees including the UK Chemicals Stakeholder Forum (Deputy Chair), EC Expert Group on Indoor Air Quality, DH Committee on the Medical Effects of Air Pollutants, the Expert Panel on Air Quality Standards, the Advisory Committee on Hazardous Substances, the Food Standard’s Agency Working Party on Chemical Contaminants in Food, and the Interdepartmental Group on Health Risks from Chemicals. He was also the founder Chairman of the UK Indoor Environments Group. He has published many scientific papers and articles on a broad range of environment and health issues, notably indoor air quality, endocrine disruption and fibre toxicology, and is on the editorial board of several distinguished journals. He is also past Chairman of the CranfieId University Health Research Ethics Committee.

Selected publications

Regulatory risk assessment approaches for synthetic mineral fibres.
Harrison P, Holmes P, Bevan R, Kamps K, Levy L & Greim H
Regulatory Toxicology and Pharmacology, 2015, 73, 425-441.

Crystalline silica in heated man-made vitreous fibres: A review.
Brown TP and Harrison PTC
Regulatory Toxicology and Pharmacology, 2014, 68, 152-159.

Fluoride in Water: a UK Perspective.
Harrison PTC
J Fluorine Chemistry, 2005, 126, 1448-1456.

Indoor air quality guidelines.
Harrison PTC
Editorial: Occup Environ Med, 2002, 59, 73-74.

Editorial: Endocrine disrupters and human health.
Harrison PTC
Brit Med J, 2001, 323, 1317-1318.

Health effects of environmental chemicals.
Harrison PTC
Pollution Causes, Effects and Control (Fourth Edition), 2001, Cambridge, UK, Royal Society of Chemistry, pp 500-523.

Hyperplastic and neoplastic changes in the lungs of rats treated concurrently with chrysotile asbestos and N-nitrosheptamethyleneimine.
Harrison PTC, Hoskins JA, Brown RC, Pigott GH, Hext PM and Mugglestone MA
Inhal Toxicol, 2000, 12 (Suppl 3), 167-172.

Comparative hazards of chrysotile asbestos and its substitutes: A European perspective.
Harrison PTC, Levy LS, Patrick G, Pigott GH and Smith LL
Environ Health Perspect, 1999, 107, 607-611.

Reproductive health in humans and wildlife: Are adverse effects associated with environmental chemical exposure?
Harrison PTC, Holmes P and Humfrey CDN
Sci Total Environ, 1997, 205, 97-106.

Paul's complete publications list

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Philip Holmes BSc, CBiol, MSB, ERT

Shortly after retirement from the role of Technical Director Chemicals Science at Risk and Policy Analysts Ltd (RPA) in 2013, Phil established IEH Consulting with Dr Harrison and Dr Bevan.  During his time at RPA (2009-2013), his responsibilities related to chemical policy and the assessment of human and environmental risks for projects commissioned by the UK Government, the European Chemicals Agency, European Commission and industry. Prior to joining RPA, he held various positions in the Institute of Environment and Health ranging from Senior Toxicology to Deputy Director of the Institute, located firstly at the University of Leicester and subsequently at Cranfield University. While at the Institute, he undertook numerous chemical risk assessments, contributed to studies to inform UK policy development and provided scientific secretariat support to the UK Co-ordinated Chemicals Risk Management Programme (CCRMP) Steering Group and advised the UK Government and non-governmental organisations on policy in relation to European chemicals regulation, on childhood health and alternatives to animal testing. During the first 18 years of his career he worked in regulatory toxicology in the contract sector investigating the safety of pharmaceuticals, agrochemicals, food additives and food contact materials.

Phil holds a degree in Zoology and was a member of the Institute of Biology (CBiol, MIBiol) 1979-2009, the Society of Biology (CBiol, MSB), 2009–2015, and of the Royal Society of Biology (CBiol, MRSB) during 2015 and 2016.  He was on the British Toxicology Society Register of Toxicologists from 1995-2016 and a EUROTOX Registered Toxicologist (ERT) from 1997 to 2016. He has over 40 years’ experience in toxicology and risk assessment, having worked extensively on a wide range of chemical classes (including pharmaceuticals, agrochemicals, food additives and industrial and consumer chemicals).  Phil’s areas of particular interest include endocrine disrupting chemicals, regulatory toxicology (including study design and assessment), and the assessment of the risk to humans from occupational and environmental exposures (including via consumer articles, drinking water, food and air).

Selected publications

Harrison P, Holmes P, Bevan R, Kamps K, Levy L & Greim H (2015) Regulatory risk assessment approaches for synthetic mineral fibers. Regulatory Toxicology & Pharmacology. Available at: http://dx.doi.org/10.10.16/j.yrtph2-15.07.029.

Occupational cancer burden in Great Britain.
Rushton L, Hutchings SJ, Fortunato L, Young C, Evans GS, Brown T, Bevan R, Slack R, HOLMES P,
Bagga S, Cherrie JW and Van Tongeren M
British Journal of Cancer, 2012, 107, Supplement 1, S3-S7.

Technical assistance to prepare the Commission Report on the operation of REACH: Study for the European Commission DG Environment by RPA and Ökopol.
HOLMES P, Tuffnell N, Jepson D, Reihlen A and Postle P
Available at http://ec.europa.eu/enterprise/sectors/chemicals/documents/reach/review2012/
commission_report_en.htm

Assessment of the Health and Environmental Benefits of REACH: Study for the European Commission
DG Environment by RPA Oekopol and DHI.
Postle M, HOLMES P, Camboni M, Salado R, Reihlen A, Jepson D and Torslov J  
A vailable at http://ec.europa.eu/enterprise/sectors/chemicals/documents/reach/review2012/
health_env_benefits_en.htm
;

A review of latest endocrine disrupting chemicals research: implications for drinking water.
Bevan R, Harrison P, Youngs L , Whelan M, Goslan E, Macadam J, HOLMES P and Persich T. Available at http://dwi.defra.gov.uk/research/completed-research/reports/DWI70_2_266.pdf

Assessing the Health and Environmental Impacts in the Context of Socio-economic Analysis under REACH. Postle M, HOLMES P, Salado R, Thorell A, Tuffnell N, Guittat A, Rushton L, Fantke P. Available at http://ec.europa.eu/environment/chemicals/reach/publications_en.htm

The mutagenicity and carcinogenicity of inorganic Mn compounds: A review of the evidence.
Assem FL, HOLMES P and Levy LS. Toxicology and Environmental Health, Part B: Critical Reviews,
2011, 14, 537-570.

The applicability of epidemiological methods to the assessment of the risk to human health of
indoor air pollution: a critical review. Brown TP, HOLMES P and Harrison PTC.
Indoor and Built Environment, 2010, 19, 311-326.

Is low-level environmental mercury exposure of concern to human health?
HOLMES P, James KAF and Levy LS. Science of the Total Environment, 2009, 408, 171-182.

A comparison of disinfection by-products found in chlorinated and chloraminated drinking waters in Scotland. Goslan EH, Krasner SW, Bower M, Rocks SA, HOLMES P, Levy LS and Parsons SA. Water Research, 2009, 43, 4698-4706.

An assessment of potential cancer risk following occupational exposure to ethanol.
Bevan RJM, Slack RJ, HOLMES P and Levy LS. Journal of Toxicology and Environmental Health, Part B, 2009, 12, 188 - 205.

Towards a Harmonised Approach to Setting Occupational Exposure Limits: Report of an ICMM-sponsored Workshop, London, 9-11 November 2005. HOLMES P, James K and Levy L. International Council on Mining and Metals, 2006, London, UK.

Prioritising veterinary medicines according to their potential indirect human exposure and toxicity profile. Capleton AC, Courage C, Rumsby P, HOLMES P, Stutt E, Boxall ABA and Levy LS. Toxicology Letters, 2006, 163, 213-223.

Information Exchange and International Co-ordination on Endocrine Disrupters
Botham C, Harrison PTC, HOLMES P, Koller K and Rumsby PC. Available at http://ec.europa.eu/environment/endocrine/documents/mrc_report.pdf#page=1.

Phil's complete publication list


Dr Ruth Bevan BSc, PhD

Ruth has acted as an independent consultant since 2015 following her departure from Cranfield University where she held the position of Senior Lecturer in Human Health Risk Assessment, within the Institute of Environment and Health. Prior to joining Cranfield University, Ruth gained a BSc (Hons) in Applied Biology and PhD in Immunochemistry. Her post-doctoral studies on the detection of free radical damage to biomolecules were carried out at the University of Leicester.

Ruth’s current expertise lie in toxicology and human health risk assessment in areas connected with environmental or occupational exposure to chemicals and she brings over 25 years’ experience to IEH Consulting. Her particular interests lie in the fields of biomarkers of both exposure and effect and in the setting of biological and occupational guidance values. Ruth has published on a broad range of environment and health issues, notably in the field of occupational cancer burden and biomonitoring of environmental exposures (including via consumer articles, drinking water, food and air). 

Ruth has extensive experience of project organisation and management for a wide range of clients. More recently she has become involved with the setting of guideline values for chemicals in drinking water and sits on the chemical expert working group for the WHO. In addition, Ruth is an editor for the Journal of Water and Health, a fellow of the Society for Biology (FSB) and a long-standing member of the British Toxicology Society. She has also past Vice Chair and acting Chair of the CranfieId University Health Research Ethics Committee.

Selected publications

Smolders R, Koch HM, Moos RK, Cocker J, Jones K, Warren N, Levy L, BEVAN R, Hays SM, Aylward LL (2014) Inter- and intra-individual variation in urinary biomarker concentrations over a 6-day sampling period. Part 1: metals. Toxicol Lett. 231(2) 249-60.

Koch HM, Aylward LL, Hays SM, Smolders R, Moos RK, Cocker J, Jones K, Warren N, Levy L, BEVAN R (2014) Inter- and intra-individual variation in urinary biomarker concentrations over a 6-day sampling period. Part 2: personal care product ingredients. Toxicol Lett. 231(2) 261-9.

Aylward LLHays SMSmolders RKoch HMCocker JJones KWarren NLevy LBEVAN R  (2014) Sources of variability in biomarker concentrations. Journal of toxicology and environmental health. Part B, Critical Reviews, 17(1) 45-61.

Rushton L, Hutchings SJ, Fortunato L, Young C, Evans GS, Brown T, BEVAN R, Slack R, Holmes P, Bagga S, Cherrie JW and Van Tongeren M (2012) Occupational cancer burden in Great Britain. British Journal of Cancer, 107, Supplement 1, S3-S7. 

BEVAN R, Young C, Holmes P, Fortunato L, Slack R and Rushton L with the British Occupational Cancer Burden Study Group (2012) Occupational cancer in Britain: Gastrointestinal cancers: liver, oesophagus, pancreas and stomach.  British Journal of Cancer, 107, Supplement 1, S33-S40.

BEVAN R, Angerer J, Cocker J, Jones K, Koch H, Levy L, Sepai O, Schoeters G, Smolders R (2012) Framework for the development and application of environmental biological monitoring guidance values. Regul Toxicol Pharmacol, 63(3), 453-60.

BEVAN R, Jones K, Cocker J, Assem L, Levy L (2012) Reference ranges for key biomarkers of chemical exposure within the UK population. International Journal of Hygiene and Environmental Health, 216(2), 170-174.

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